Global dengue burden examined
The global burden of dengue infection is more than triple current estimates from the World Health Organization (WHO), according to a multinational study published online in the journal Nature. The research has created the first detailed and up-to-date map of dengue distribution worldwide, enabling researchers to estimate the total number of people affected by the virus globally, regionally and nationally. The findings will help to guide efforts in vaccine, drug and vector control strategies. The study was led by Professor Simon Hay, a Wellcome Trust senior research fellow at the University of Oxford, UK, as part of the International Research Consortium on Dengue Risk Assessment, Management and Surveillance. There are currently no licensed vaccines or specific treatments for dengue, and substantial efforts to control the mosquitoes that transmit the disease have not stopped its rapid emergence and global spread. Dr Samir Bhatt, who led the modelling for the study, said: “Our aim was to take all of the evidence that is currently available on the distribution of dengue worldwide and combine it with the latest in mapping and mathematical modelling to produce the most refined risk maps and burden estimates. We then hope to use this knowledge to help predict the future burden of the disease.”
The global burden of dengue infection is more than triple current estimates from the World Health Organization (WHO), according to a multinational study published online in the journal Nature. The research has created the first detailed and up-to-date map of dengue distribution worldwide, enabling researchers to estimate the total number of people affected by the virus globally, regionally and nationally. The findings will help to guide efforts in vaccine, drug and vector control strategies. The study was led by Professor Simon Hay, a Wellcome Trust senior research fellow at the University of Oxford, UK, as part of the International Research Consortium on Dengue Risk Assessment, Management and Surveillance. There are currently no licensed vaccines or specific treatments for dengue, and substantial efforts to control the mosquitoes that transmit the disease have not stopped its rapid emergence and global spread. Dr Samir Bhatt, who led the modelling for the study, said: “Our aim was to take all of the evidence that is currently available on the distribution of dengue worldwide and combine it with the latest in mapping and mathematical modelling to produce the most refined risk maps and burden estimates. We then hope to use this knowledge to help predict the future burden of the disease.”
The findings reveal that dengue is ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by rainfall, temperature and urbanisation. The team estimates that there are 390 million dengue infections across the globe each year, of which 96 million reach some level of clinical or subclinical severity. This is more than triple the WHO’s most recent estimates of 50 to 100 million infections per year. Professor Simon Hay explains: “We found that climate and population spread were important factors for predicting the current risk of dengue around the world. With globalisation and the constant march of urbanisation, we anticipate that there could be dramatic shifts in the distribution of the disease in the future: the virus may be introduced to areas that previously were not at risk, and those that are currently affected may experience increases in the number of infections. We hope that the research will initiate a wider discussion about the significant global impact of this disease.”
Of the 96 million apparent infections, Asia bore 70 per cent of the burden, shows the report, while India alone accounted for around one-third of all infections. The results further indicate that with 16 million infections, Africa’s burden is almost equivalent to that of the Americas and is significantly larger than previously appreciated. The authors suggest that the hidden African dengue burden could be a result of the disease being masked by symptomatically similar illnesses, under-reporting and highly variable treatment-seeking behaviour.
Professor Jeremy Farrar, director of the Wellcome Trust Vietnam Research Programme and Oxford University Clinical Research Unit Hospital for Tropical Diseases in Vietnam, explained that the map and estimates produced by Hay’s group set the benchmark for the disease: “This is the first systematic robust estimate of the extent of dengue. The evidence that we’ve gathered here will help to maximise the value and cost-effectiveness of public health and clinical efforts, by indicating where limited resources can be targeted for maximum possible impact.”
With endemic transmission in Asia and the Americas, recent outbreaks in Portugal, the ever-increasing incidence in Africa, and the challenges of making an effective dengue vaccine or controlling the vector, Professor Farrar stresses: “This really does represent a crucial period in the global spread of dengue.”